글 보기

SCI 논문 게재(한국식품과학회지 2021년 12월 Accept, 2022년 1월 게재)

작성자 : 한준희 작성일 : 2022-04-04 13:29:29 조회수 : 621


Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell


Food Science and Biotechnology ( 한국식품과학회지 영문지 SCI)


2022 1 , 31(1):121-129


Rosa rugosa root is traditionally known to be effective in the treatment of diabetes in Korea. R. rugosa root-speci c compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clari ed. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of R. rugosa (REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (PPARc), CCAAT/enhancer binding protein alpha (C/EBPa), and sterol regulatory element binding protein1 (SREBP1c) and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.