제목

Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell

게재지

Food Science and Biotechnology ( 한국식품과학회지 영문지 SCI)

발행일

2022 년 1 월 , 31(1):121-129

Abstract

Rosa rugosa root is traditionally known to be effective in the treatment of diabetes in Korea. R. rugosa root-speci fi c compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clari fi ed. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of R. rugosa (REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (PPARc), CCAAT/enhancer binding protein alpha (C/EBPa), and sterol regulatory element binding protein1 (SREBP1c) and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.